Prevention and treatment of drug resistance in cancer

Runxuan Zhao

doi:10.1117/12.2692192

7 September 2023 Prevention and treatment of drug resistance in cancer

Runxuan Zhao

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127892W (2023) https://doi.org/10.1117/12.2692192
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Cancer is a complex disease and the single greatest obstacle to increasing life expectancy worldwide in modern times. Cancer is generally characterized by uncontrolled proliferation of cells, a decline in apoptosis and irregular cell cycle. Currently among all cancers, the highest indecency of malignancy is lung cancer. Currently, therapies, including chemotherapy, serves as a core part for battling against cancer. However, a serious obstacle to treating cancer is cancer drug resistance. At least five mechanisms, including tumor microenvironment, tumor heterogeneity, decreased drug uptake, drug efflux and DNA repair alteration, are involved in the acquirement of anti-cancer drug resistance. On the other hand, new approaches have been developed and designed to target anti-cancer drug resistance. Understanding mechanistically the triggers of cancer medication tolerance contributes to another critical aspect for anti-drug resistance. First-round drugs of choice as initial chemotherapy is crucial and thus requires great attention to avoid the development of anti-cancer drug resistance.

Citation Download Citation

Runxuan Zhao "Prevention and treatment of drug resistance in cancer", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127892W (7 September 2023); https://doi.org/10.1117/12.2692192

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