Visualization of topical drug delivery with label-free chemical imaging

Natalie A. Belsey; Vasundhara Tyagi; Jean-Luc Vorng; Alex Dexter; Dimitrios Tsikritsis; Panagiota Zarmpi; Richard H. Guy

doi:10.1117/12.3008776

12 March 2024 Visualization of topical drug delivery with label-free chemical imaging

Natalie A. Belsey, Vasundhara Tyagi, Jean-Luc Vorng, Alex Dexter, Dimitrios Tsikritsis, Panagiota Zarmpi, Richard H. Guy

Author Affiliations +

Proceedings Volume 12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; 1282107 (2024) https://doi.org/10.1117/12.3008776
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Recent advances in label-free chemical imaging approaches have yielded new methods for measuring drug distribution in biological tissues. Such techniques include Raman spectroscopy and multiphoton microscopies, in addition to a suite of powerful mass spectrometry imaging methods. These techniques offer complementary information, with different strengths and limitations. By combining several of these datasets using image registration, powerful visualization can be achieved, combining high chemical specificity and sensitivity with sub-micron spatial resolution. Here we present a correlative imaging example that combines nonlinear optical spectroscopies and secondary ion mass spectroscopy imaging, applied to the same skin sample, for label-free visualization of the tissue structure and the distribution of an applied model compound.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Natalie A. Belsey, Vasundhara Tyagi, Jean-Luc Vorng, Alex Dexter, Dimitrios Tsikritsis, Panagiota Zarmpi, and Richard H. Guy "Visualization of topical drug delivery with label-free chemical imaging", Proc. SPIE 12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, 1282107 (12 March 2024); https://doi.org/10.1117/12.3008776

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