Quantitative tissue biodistribution of fluorescence imaging agents in orthotopic mouse model of head and neck squamous cell carcinoma

Yichen Feng; Cody Rounds; Kenneth M. Tichauer; Kimberley S. Samkoe

doi:10.1117/12.3002872

12 March 2024 Quantitative tissue biodistribution of fluorescence imaging agents in orthotopic mouse model of head and neck squamous cell carcinoma

Yichen Feng, Cody Rounds, Kenneth M. Tichauer, Kimberley S. Samkoe

Author Affiliations +

Proceedings Volume 12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; 1282108 (2024) https://doi.org/10.1117/12.3002872
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Accurate characterization of tissue biodistribution (BD) is essential for the development of new drug and imaging agents. Recently, a novel method to quantify tissue-specific BD of fluorescent imaging agent has been developed and characterized. A subsequent tissue BD study, using this method, was performed in mice with subcutaneous tumor xenograft of head and neck squamous cell carcinoma (NHSCC). Here we utilized the same method to characterize tissue BD of two imaging agents, ABY-029 and IRDye 680LT in mouse orthotopic HNSCC tumor model. Tissue-specific fluorescence intensities were measured 5h after imaging agent administration. The two imaging agents shared similar trends of relative fluorescence intensities across ten types of tissue. Highest tissue-specific fluorescence values were observed in kidney and liver for both imaging agents while brain and muscle showed the lowest distribution for both agents.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yichen Feng, Cody Rounds, Kenneth M. Tichauer, and Kimberley S. Samkoe "Quantitative tissue biodistribution of fluorescence imaging agents in orthotopic mouse model of head and neck squamous cell carcinoma", Proc. SPIE 12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, 1282108 (12 March 2024); https://doi.org/10.1117/12.3002872

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