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The validation of the porcine model as a reliable and effective platform for in vitro and vivo dose-escalation trials is central to the success of this study. This model has been extensively studied and proven to be a valuable tool in biomedical research due to its anatomical and physiological similarities to humans. This model has the potential to refine irradiation parameters and investigate immunologic responses for consistent results. These parameters are crucial for attaining the desired therapeutic outcomes and vary depending on clinical conditions, treatment objectives, and the characteristics of the target tissue. The porcine model has proven to be a highly versatile subject in a wide range of biological research fields. Its usefulness extends to studies on nerve regeneration, immunology, bone biology, and titanium osseointegration, among others. Researchers have found that the similarities between porcine and human physiology make this model an excellent tool for advancing our understanding of complex biological processes. The porcine model can facilitate various light dose escalation trial formats while enabling comprehensive assessments that integrate in vivo dosimetry. This model can also be expanded to characterize tissue optical properties, CT analysis, tissue histology, immune cell profiling, inflammatory response evaluation, histomorphometry, and biomechanical testing. This approach creates a translational framework to integrate in vivo dose-escalation trials and reinforces the importance of precision light dosimetry analysis. |
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