Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

Linas Jonušauskas; Eglė Vitkūnaitė; Dovilė Andrijec; Konradas Stonkus; Grzegorz Kaszynski

doi:10.1117/12.3001435

12 March 2024 Beam-shaping enhanced two-photon polymerization: towards 3D medical printing

Linas Jonušauskas, Eglė Vitkūnaitė, Dovilė Andrijec, Konradas Stonkus, Grzegorz Kaszynski

Proceedings Volume 12876, Laser 3D Manufacturing XI; 1287602 (2024) https://doi.org/10.1117/12.3001435
Event: SPIE LASE, 2024, San Francisco, California, United States

Abstract

Two-photon polymerization (2PP) based 3D printing is a well-established technique. However, for the vast majority of its existence, 2PP was realized by applying general-purpose setups that were not tailored to any specific field. This resulted in limitations regarding how much 2PP can proliferate in any one particular area. Therefore, in this work, we will explore what can be achieved if a 2PP setup is built from the ground up for usage in one specific field - biomedical 3D printing. To achieve it a special femtosecond (fs) laser-based setup is assembled with integrated dynamic beam-shaping. Removal of zero order maximum in such an optical setup is demonstrated, and main related peculiarities are discussed. Then the beam-shaping is used to elongate voxels allowing to improve manufacturing throughput by more than two orders of magnitude. We then used the setup and developed voxel elongation methodology to produce biology-oriented structures, such as stents, grafts, and organoid scaffolds. We show excellent biocompatibility and cell growth on the later structures. Overall, the presented results show how focusing on 2PP system design to accommodate one particular field, in this case, biomedicine, helps to exploit the system’s capabilities beyond what general purpose 2PP setup could achieve.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Linas Jonušauskas, Eglė Vitkūnaitė, Dovilė Andrijec, Konradas Stonkus, and Grzegorz Kaszynski "Beam-shaping enhanced two-photon polymerization: towards 3D medical printing", Proc. SPIE 12876, Laser 3D Manufacturing XI, 1287602 (12 March 2024); https://doi.org/10.1117/12.3001435

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