Advances in immunotherapy for colorectal cancer

Dongxu Chen

doi:10.1117/12.3012907

8 January 2024 Advances in immunotherapy for colorectal cancer

Dongxu Chen

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129242P (2024) https://doi.org/10.1117/12.3012907
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

The colon or the rectum is where colorectal cancer (CRC) first appears. Depending on where they first appear, these malignancies may also go by the names colon cancer or rectal cancer. These two belong to the digestive system. Adenomatous polyps, which are tiny, benign (noncancerous) clusters of cells, are the normal precursors of colorectal cancer. Over time, some of these polyps can turn into colorectal cancer. CRC was the third most common cancer in male, and it is the second in female globally in 2020. Although traditional treatment modalities like surgery, chemotherapy, and radiation therapy have made significant advancements, they still have significant limitations because a sizable proportion of patients either show resistance to these protocols or experience disease recurrence after treatment. The development of immunotherapy, a method that regulates the natural immune system to fight against cancerous cells, represents a hopeful expansion of the range of treatment options for CRC. With the rapid development of technologies, more effective therapies are emerging. This review offers a thorough review of the state-of-the-art immunotherapeutic approaches for CRC, taking into account adoptive cell therapy, immune checkpoint inhibitors, biomarkers indicative of treatment response, and the use of immune checkpoint inhibitors.

Citation Download Citation

Dongxu Chen "Advances in immunotherapy for colorectal cancer", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129242P (8 January 2024); https://doi.org/10.1117/12.3012907

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