Current trends for therapeutic cancer vaccine adjuvant development

Fanke Chen

doi:10.1117/12.3013152

8 January 2024 Current trends for therapeutic cancer vaccine adjuvant development

Fanke Chen

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129243J (2024) https://doi.org/10.1117/12.3013152
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Cancer is a disease in which cancer cells divide out of control, infiltrating and destroying normal body tissues, and spreading throughout the body. It has been reported that the second leading cause of death in the world today is cancer. According to statistics, in 2020, 10 million people died of cancer, including 1.8 million from lung cancer, 916,000 from colon and rectal cancer, 830,000 from liver cancer, 769,000 from stomach cancer and 685,000 from breast cancer. Traditional cancer treatments, such as surgical intervention, radiation, and taking chemotherapeutic drugs can have significant side effects and result in toxicity in patients. Therefore, effective cancer treatment is under the exploration. Vaccines are now considered to be one the most promising cancer treatments. By causing the body's immune system to target and stop the growth of cancer cells, cancer vaccines can prevent and treat cancer with fewer side effects. In this review, the components, mechanisms and latest clinical trials of DNA and RNA vaccines, proteins or synthetic peptides of cancer antigens and delivery of tumour antigens to cells are mainly introduced. In addition, vaccine construction and applications of different types of vectors, such as lipid-based delivery and polymer-based delivery methods are also in discussion.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Fanke Chen "Current trends for therapeutic cancer vaccine adjuvant development", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129243J (8 January 2024); https://doi.org/10.1117/12.3013152

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KEYWORDS

Cancer

Polymers

Tumors

Lung cancer

Proteins

Clinical trials

Colorectal cancer

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