Laser-induced luminescence of singlet molecular oxygen: generation by drugs and pigments of biological importance

Sergei Yu. Egorov; Alexander A. Krasnovsky Jr.

doi:10.1117/12.57282

1 May 1991 Laser-induced luminescence of singlet molecular oxygen: generation by drugs and pigments of biological importance

Sergei Yu. Egorov, Alexander A. Krasnovsky Jr.

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Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57282
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

The photon counting technique and flashlaser excitation were applied to the timeresolved measurement of photosensitized singlet oxygen luminescence in organic and aqueous media. The quantum yields for singlet oxygen generation have been measured in solutions of photosynthetic pigments synthetic and natural porphyrins porphyrins conjugated with monoclonal antibodies furocoumarins flavins fluorescein tetracycline and endogenous photosensitizers of human lens. The data obtained indicate that the measurement of the singlet oxygen luminescence is a reliable tool to study the photosensitizing activity of drugs and to elucidate primary mechanisms of photodynamic destruction. 1.

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Sergei Yu. Egorov and Alexander A. Krasnovsky Jr. "Laser-induced luminescence of singlet molecular oxygen: generation by drugs and pigments of biological importance", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57282

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