Visualization of electron transfer interactions of membrane proteins

Suguru Kawato

doi:10.1117/12.44671

1 August 1991 Visualization of electron transfer interactions of membrane proteins

Suguru Kawato

Proceedings Volume 1429, Holography, Interferometry, and Optical Pattern Recognition in Biomedicine; (1991) https://doi.org/10.1117/12.44671
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

To visualize electron transfer interactions of proteins in the cellular nieinbrane, we have developed a polarized laser flash-induced anisotropy decay imaging. The time-resolved anisotropy is particularly sensitive to protein-protein interactions. This technique has been successfully applied to examine formation and dissociation of electron transfer complex in adrenal cortex and liver. Electron transfer plays a significant role for steroid hormone synthesis from cholesterol in adrenalcortex and for drug metabolism in liver such as detoxification of chemical compounds. Several redox partners perticipate in dynamic electron transfer interactions. The terminal enzyme cytochrome P-450 receives electrons to activate molecular oxygen, resulting in hydroxylation of various substrates.

Citation Download Citation

Suguru Kawato "Visualization of electron transfer interactions of membrane proteins", Proc. SPIE 1429, Holography, Interferometry, and Optical Pattern Recognition in Biomedicine, (1 August 1991); https://doi.org/10.1117/12.44671

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