Photodynamic diagnosis of early stage malignancies: preliminary results in urology and pneumonology

Reinhold Baumgartner; M. Kriegmair; Dieter Jocham; Alfons G. Hofstetter; Rainer Huber; O. Karg; Karl Haeussinger

doi:10.1117/12.59354

6 May 1992 Photodynamic diagnosis of early stage malignancies: preliminary results in urology and pneumonology

Reinhold Baumgartner, M. Kriegmair, Dieter Jocham, Alfons G. Hofstetter, Rainer Huber, O. Karg, Karl Haeussinger

Proceedings Volume 1641, Physiological Monitoring and Early Detection Diagnostic Methods; (1992) https://doi.org/10.1117/12.59354
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

on the basis of clinical protocols, phase Il-studies have been started to evaluate photodynamic diagnosis (PDD) for early visualization of cancer in bladder and lung. As tumor marker the fluorescent and photosensitizing polyporphyrin Photofrin II is used in a dose, which has been proven to avoid photosensitization of the patients skin. The drug is administered systemically in a concentration of mostly 0,4 mg/kg bodyweight. Fluorescence of Photofrin II in tissue is detected by an image intensifying CCD-camera coupled to endoscopes usually used in both medical disciplines. Video presentation of the marker fluorescence occurs with high contrast due to realtime image processing following two wavelength excitation of the tissue with laser light. Keypoint of the new diagnostic method is the correlation of the fluorescence contrast and the histological examination of biopsies removed from these areas. As example 87 biopsies has been taken from 1 7 patients suffering from bladder cancer. While all tumorous samples (n = 1 6) show strong fluorescence, about 30% of the biopsies are judged as false positive. A variety of premalignant diseases has been found in these sections. No false negative results are obtained up to now.

Citation Download Citation

Reinhold Baumgartner, M. Kriegmair, Dieter Jocham, Alfons G. Hofstetter, Rainer Huber, O. Karg, and Karl Haeussinger "Photodynamic diagnosis of early stage malignancies: preliminary results in urology and pneumonology", Proc. SPIE 1641, Physiological Monitoring and Early Detection Diagnostic Methods, (6 May 1992); https://doi.org/10.1117/12.59354

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available