Photodynamic method of diagnosis and treatment of intraocular melanoma

Tadeusz Kecik; Iwona Switka-Wieclawska; Jan Kasprzak; Alfreda Graczyk; Antoni Pratnicki

doi:10.1117/12.147542

24 June 1993 Photodynamic method of diagnosis and treatment of intraocular melanoma

Tadeusz Kecik, Iwona Switka-Wieclawska, Jan Kasprzak, Alfreda Graczyk, Antoni Pratnicki

Proceedings Volume 1877, Ophthalmic Technologies III; (1993) https://doi.org/10.1117/12.147542
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Malignant melanoma is the most prevalent and the most dangerous primary intraocular tumor. The most common treatment until recently was enucleation. In our experimental work we would like to present the use of hematoporphyrin derivative photodynamic therapy (HpD- PDT) in diagnosis and treatment of cancer. Eighteen eyes of rabbits were incubated intracamerally with amelanotic Greene melanoma tissue. The technique involves the administration of HpD and photoactivation of the tumor with violet light (406 nm) for diagnostic purposes and with red light (630 nm) to achieve selective destruction of cancer cells. After photoradiation the tumor showed blanching and shrinkage, we could also observe the tumor vasculature damage. Successfully treated tumors had large areas of necrosis with severely damaged blood vessels in histopathological examination. Results indicate that HpD- PDT is a very promising modern modality offering new diagnostic and treatment methods for melanoma.

Citation Download Citation

Tadeusz Kecik, Iwona Switka-Wieclawska, Jan Kasprzak, Alfreda Graczyk, and Antoni Pratnicki "Photodynamic method of diagnosis and treatment of intraocular melanoma", Proc. SPIE 1877, Ophthalmic Technologies III, (24 June 1993); https://doi.org/10.1117/12.147542

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