Dual imaging of arterial walls: intravascular ultrasound and fluorescence spectroscopy

Karl A. Pope; Steve Warren; Youseph Yazdi; Alfred L. Johnston; Michael Davis M.D.; Rebecca R. Richards-Kortum

doi:10.1117/12.146589

23 June 1993 Dual imaging of arterial walls: intravascular ultrasound and fluorescence spectroscopy

Karl A. Pope, Steve Warren, Youseph Yazdi, Alfred L. Johnston, Michael Davis M.D., Rebecca R. Richards-Kortum

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146589
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

This paper describes a combined ultrasonic and spectroscopic system for imaging both the structure and chemical composition of atherosclerotic plaque. Using this system, ultrasound pulse echo distance estimations can be used to accurately compensate detected tissue fluorescence intensities for a wide range of tissue-detector separations, D. Compensation is achieved using an empirical model, wherein fluorescence intensity decreases as 1/Dⁿ with n equals 1.1 for tissue detector separations from 2.5 to 5 mm and 1.4 for separations of 5 to 15 mm. This behavior indicates that fluorescence exiting the tissue surface is not isotropic.

Citation Download Citation

Karl A. Pope, Steve Warren, Youseph Yazdi, Alfred L. Johnston, Michael Davis M.D., and Rebecca R. Richards-Kortum "Dual imaging of arterial walls: intravascular ultrasound and fluorescence spectroscopy", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146589

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