Primary photoprocesses in photomodified porphyrins: considerations on tumor therapy

Ricardas Rotomskis; Barbara E. Krammer

doi:10.1117/12.146206

17 June 1993 Primary photoprocesses in photomodified porphyrins: considerations on tumor therapy

Ricardas Rotomskis, Barbara E. Krammer

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146206
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

The irradiation of an aqueous solution of the hematoporphyrin causes the formation of the stable photoproduct that may play an important role in the cancer therapy. The spectral and kinetic characteristics of the absorption changes of hematoporphyrins and their photoproducts were measured by picosecond pump and probe absorption spectrophotometer with continuous tunability of pump and probe pulses in the spectral region of 400 - 1500 nm with an accuracy better than 10^-3 optical units and with the temporal resolution less than 10 ps. The careful examination of the absorption difference spectra showed that the photoproduct is involved in aggregates or exists as a part of the covalently linked oligomer of hematoporphyrins. In addition, an in vitro investigation has been carried out in the solutions and cells to evaluate the influence of preillumination of porphyrins on the efficiency of damaging the cell's membrane integrity after irradiation by red light.

Citation Download Citation

Ricardas Rotomskis and Barbara E. Krammer "Primary photoprocesses in photomodified porphyrins: considerations on tumor therapy", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146206

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