Pharmakokinetics of 132-hydroxy-bacteriopheophorbide: a methyl ester studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice

Beate Roeder; Cathrin Dressler; B. Fuchs; Roland Hagemann; Hans-Peter Berlien; Christian Nowak; Joerg G. Moser

doi:10.1117/12.168685

1 March 1994 Pharmakokinetics of 132-hydroxy-bacteriopheophorbide: a methyl ester studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice

Beate Roeder, Cathrin Dressler, B. Fuchs, Roland Hagemann, Hans-Peter Berlien, Christian Nowak, Joerg G. Moser

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168685
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

The pharmacokinetics of 13²-hydroxy-bacteriopheophorbide a methyl ester (OH-BPME) was studied on Lewis lung carcinoma bearing mice by fluorescence spectroscopy. The sensitizer distribution in different organs and in the tumor was investigated in dependence on the incubation time. A very fast cleaning of the blood and the skin was observed. The results of our investigations suggest that PDT using OH-BPME could be effective at sensitizer incubation times of about 12 h.

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Beate Roeder, Cathrin Dressler, B. Fuchs, Roland Hagemann, Hans-Peter Berlien, Christian Nowak, and Joerg G. Moser "Pharmakokinetics of 132-hydroxy-bacteriopheophorbide: a methyl ester studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168685

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