Aggregation and deformation of red blood cells as probed by a laser light scattering technique in a concentrated suspension: comparison between normal and pathological red blood cells

Amir H. Gandjbakhche; Ali Othmane; Pierre Mills; Patrick Snabre; Jacques Dufaux

doi:10.1117/12.180776

21 July 1994 Aggregation and deformation of red blood cells as probed by a laser light scattering technique in a concentrated suspension: comparison between normal and pathological red blood cells

Amir H. Gandjbakhche, Ali Othmane, Pierre Mills, Patrick Snabre, Jacques Dufaux

Author Affiliations +

Proceedings Volume 2136, Biochemical Diagnostic Instrumentation; (1994) https://doi.org/10.1117/12.180776
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Changes in aggregability and/or deformability of red blood cells (RBC) can cause severe complications in blood circulation. We use a laser light scattering technique, which can distinguish between normal and pathological RBCs by studying the angular distributions of backscattered and transmitted light of concentrated suspensions of RBCs submitted to a simple shear flow. In order to study the deformation, we induced partial rigidity in the RBC membrane, and showed that the gradients of deformation and the relaxation times of normal and partially rigidified RBC membranes can be quantified using a non-Newtonian rheological model. We observe that blood aggregation of patients with `microcirculatory' diseases, such as diabetes, differs from that of healthy individuals.

Citation Download Citation

Amir H. Gandjbakhche, Ali Othmane, Pierre Mills, Patrick Snabre, and Jacques Dufaux "Aggregation and deformation of red blood cells as probed by a laser light scattering technique in a concentrated suspension: comparison between normal and pathological red blood cells", Proc. SPIE 2136, Biochemical Diagnostic Instrumentation, (21 July 1994); https://doi.org/10.1117/12.180776

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available