Artificial trabeculum (MESH) for glaucoma surgery

Valerie Jallet; Jean-Marie A. Parel; Takaaki Matsui; Hirohiko Kato M.D.; William E. Lee; Ivan Haefliger; Mikio Sasoh M.D.; Donald Budenz; Michele Savoldelli; Yves Pouliquen

doi:10.1117/12.209860

22 May 1995 Artificial trabeculum (MESH) for glaucoma surgery

Valerie Jallet, Jean-Marie A. Parel, Takaaki Matsui, Hirohiko Kato M.D., William E. Lee, Ivan Haefliger, Mikio Sasoh M.D., Donald Budenz, Michele Savoldelli, Yves Pouliquen

Author Affiliations +

Proceedings Volume 2393, Ophthalmic Technologies V; (1995) https://doi.org/10.1117/12.209860
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

To avoid the post-operative hypotony that often occurs with ab interno and ab externo laser sclerestomies, trabeculectomies, setons and glaucoma implants, we designed the MESH, an implant that mimics the physiological meshwork. It is a sub miniature `T' shaped pouch made of thin porous poly(tetrafluoroethylene) (PTFE). An instrument allows its intrascleral insertion via 2 mm wide conjunctival incision with the MESH's head protruding in the anterior chamber's angle. Flow was assessed in five PTFE membranes of 5 to 80 micrometers pore size. Prototype implants were tested for integrity by scanning electron microscopy and in vivo studies were undertaken with MESH implants made of 20 and 50 micrometers (8 rabbits, 3 months follow-up) and 10 micrometers (11 rabbits, ongoing) PTFE membranes. Flow rates were 150 to 650 times the normal 2 (mu) l/mn physiological aqueous outflow. Surgery took about 7 minutes. The implants became translucent after 7 days and were found biocompatible over the 3 months follow-up period. The 50 micrometers implant was biocolonized in 21 days but only a few cells were observed at 3 months in the 20 micrometers implant which produced a longer lasting bleb and IOP lowering effect. No colonization is expected in the 10 micrometers material which has a higher flow rate and geometric integrity. The MESH appears safe and efficient in prolonging filtration in rabbits in the short term. To prevent cellular penetration and an adequate regulation of the aqueous flow, an expanded PTFE material with 10 - 20 micrometers pores and a 100 micrometers thickness seems best suited for the fabrication of artificial meshwork implants for use in glaucoma patients.

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Valerie Jallet, Jean-Marie A. Parel, Takaaki Matsui, Hirohiko Kato M.D., William E. Lee, Ivan Haefliger, Mikio Sasoh M.D., Donald Budenz, Michele Savoldelli, and Yves Pouliquen "Artificial trabeculum (MESH) for glaucoma surgery", Proc. SPIE 2393, Ophthalmic Technologies V, (22 May 1995); https://doi.org/10.1117/12.209860

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