Enhancement of the efficiency of photodynamic therapy by combination with the microtubule inhibitor vincristine

Li Wei Ma; Kristian Berg; Havard E. Danielsen; Vladimir Iani; Johan Moan

doi:10.1117/12.230984

31 January 1996 Enhancement of the efficiency of photodynamic therapy by combination with the microtubule inhibitor vincristine

Li Wei Ma, Kristian Berg, Havard E. Danielsen, Vladimir Iani, Johan Moan

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230984
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Combination effects of photodynamic therapy (PDT) with meso-tetra (di-adjacent- sulfonatophenyl) porphine (TPPS_2a) and the microtubule (MT) inhibitor, vincristine (VCR), were studied in the CaD2 mouse tumor model in mice. A synergistic effect was found when VCR, at an almost nontoxic dose (1 mg/kg), was injected i.p. into the mice 6 hr before PDT. The data on mitotic index show a 4 - 5 fold accumulation of the cells in mitosis 6 hr after injection of VCR into the mice. Cell cycle and ploidy distributions in tumor tissues were determined by means of image analysis with measurement of integrated optical density after Feulgen reaction on monolayers. Ploidy distribution of the tumors was not significantly changed 6 and 12 hr after administration of VCR only, while an increasing aneuploidy was observed 24 and 48 hr after VCR treatment. No prominent changes of the cell cycle and ploidy distributions were found in the tumor tissues after PDT or PDT combined with VCR.

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Li Wei Ma, Kristian Berg, Havard E. Danielsen, Vladimir Iani, and Johan Moan "Enhancement of the efficiency of photodynamic therapy by combination with the microtubule inhibitor vincristine", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230984

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