Monofunctional phthalocyanine derivatives as potential sensitizers for PDT

Dieter Wohrle; Andrea Weitemeyer; Abdol Khezer Sobbi; Ulrike Michelsen; H. Kliesch

doi:10.1117/12.230956

31 January 1996 Monofunctional phthalocyanine derivatives as potential sensitizers for PDT

Dieter Wohrle, Andrea Weitemeyer, Abdol Khezer Sobbi, Ulrike Michelsen, H. Kliesch

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230956
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Syntheses, singlet oxygen ¹O₂ quantum yields ((Phi) _(Delta )) and photostability of new monofunctional, long wavelength absorbing (680 - 750 nm) porphyrazines are reported. For the coupling to biomolecules without crosslinking reactions the sensitizers contain one reactive polar sulfo, carboxy, amino, hydroxy, or pyridyloxy group. Besides, the sensitizers are substituted by lipophilic tert-butyl, tert-butylphenoxy or alkoxy groups in order to introduce an intramolecular polarity axis for better cellular uptake and to increase solubility in organic solvents.

Citation Download Citation

Dieter Wohrle, Andrea Weitemeyer, Abdol Khezer Sobbi, Ulrike Michelsen, and H. Kliesch "Monofunctional phthalocyanine derivatives as potential sensitizers for PDT", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230956

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