In-vivo assessment of total body protein in rats by prompt-gamma neutron activation analysis

Ion E. Stamatelatos; Carol N. Boozer; Ruimei Ma; Seiichi Yasumura

doi:10.1117/12.267937

27 February 1997 In-vivo assessment of total body protein in rats by prompt-γ neutron activation analysis

Ion E. Stamatelatos, Carol N. Boozer, Ruimei Ma, Seiichi Yasumura

Proceedings Volume 2867, International Conference Neutrons in Research and Industry; (1997) https://doi.org/10.1117/12.267937
Event: Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, 1996, Crete, Greece

Abstract

A prompt-(gamma) neutron activation analysis facility for in vivo determination of total body protein (TBP) in rats has been designed. TBP is determined in vivo by assessment of total body nitrogen. The facility is based on a ²⁵²Cf radionuclide neutron source within a heavy water moderator assembly and two NaI(Tl) scintillation detectors. The in vivo precision of the technique, as estimated by three repeated measurements of 15 rats is 6 percent, for a radiation dose equivalent of 60 mSv. The radiation dose per measurement is sufficiently low to enable serial measurements on the same animal. MCNP-4A Monte Carlo transport code was utilized to calculate thermal neutron flux correction factors to account for differences in size and shape of the rats and calibration phantoms. Good agrement was observed in comparing body nitrogen assessment by prompt-(gamma) neutron activation and chemical carcass analysis.

Citation Download Citation

Ion E. Stamatelatos, Carol N. Boozer, Ruimei Ma, and Seiichi Yasumura "In-vivo assessment of total body protein in rats by prompt-γ neutron activation analysis", Proc. SPIE 2867, International Conference Neutrons in Research and Industry, (27 February 1997); https://doi.org/10.1117/12.267937

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