Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice

Zhao-Hui Jin; Norio Miyoshi; Kazumori Ishiguro; Izumi Maruyama; Isao Sakata; Keigo Takaoka; Takeshi Udagawa; Susumu Nakajima; Keichi Ueda; Fukuda Masaru; Masanobu Kumakiri

doi:10.1117/12.330180

2 November 1998 Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice

Zhao-Hui Jin, Norio Miyoshi, Kazumori Ishiguro, Izumi Maruyama, Isao Sakata, Keigo Takaoka, Takeshi Udagawa, Susumu Nakajima, Keichi Ueda, Fukuda Masaru, Masanobu Kumakiri

Author Affiliations +

Proceedings Volume 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery; (1998) https://doi.org/10.1117/12.330180
Event: 1997 Shanghai International Conference on Laser Medicine and Surgery, 1997, Shanghai, China

Abstract

In recent years, the effect of ultrasound (US) in combination with porphyrins such as a gallium-porphyrin complex (ATX-70) has been reported in the treatment of experimental cancers. Before clinical application of this method, further studies are needed. The transplanted squamous cell carcinomas (5CC) on C3H/He mice were irradiated by a tunable optical parametric oscillator (OPO) laser light or ultrasound, in the presence of several different photosensitizers. The tumor size and survival of mice after treatment were observed. Furthermore, we compared antitumor effects of combined irradiation of laser light and ultrasound with those of single laser light or ultrasound, in the presence of ATX-70 or a pheoforbide derivative (PH-1126). Besides PH-i 126 and ATX-70, the following sensitizers were tested: Photofrin II (Pf-II), hematoporphyrin oligomer (HpO). 5-aminolevulinic acid (5-ALA) and aluminum phthalocyanine tetrasuiphonate (AIPcS4). In the results, it was good effects of antitumor by the laser light treatment in the case of PH-1126 and AIPcS4, ATX-70, HpO nsd AIPcS4 produced betterantitumor effeets by irradiation with ultrasound. The antitumor effects of combined use of laser fight and ultrasound were stronger than those of single laser light or ultrasound in both cases of PH-i 126 and ATX-70. Key words: OPO laser light, ultrasound, PH-1126. ATX-70

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Zhao-Hui Jin, Norio Miyoshi, Kazumori Ishiguro, Izumi Maruyama, Isao Sakata, Keigo Takaoka, Takeshi Udagawa, Susumu Nakajima, Keichi Ueda, Fukuda Masaru, and Masanobu Kumakiri "Combined effects of photodynamic and sonodynamic treatment on experimental skin cancer on C3H mice", Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); https://doi.org/10.1117/12.330180

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