96-channel microplate surface plasmon resonance fiber optic sensor system

Ralph C. Jorgenson; Mark C. Siegfried

doi:10.1117/12.346756

21 April 1999 96-channel microplate surface plasmon resonance fiber optic sensor system

Ralph C. Jorgenson, Mark C. Siegfried

Proceedings Volume 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II; (1999) https://doi.org/10.1117/12.346756
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

A surface plasmon resonance fiber optic system is presented for the simultaneous analysis of ninety-six micro-well plates for purposes of high throughput biochemical screening analysis. The sensing element is compared of ninety-six discrete fiber optic sensor housed in a containment plate. A white light source is used to introduce light to the sensor via a multiplexed fiber optic bundle. The transmitted spectral intensity distribution of each sensor is detected via a multiplexed fiber optic bundle. The transmitted spectral intensity distribution of each sensor is detected simultaneously using a lens-based holographic imaging spectrograph and a 2D CCD detector. Experimental results confirm the feasibility of the application of this label free and real-time transduction mechanism of surface plasmon resonance towards high throughput biochemical analysis.

Citation Download Citation

Ralph C. Jorgenson and Mark C. Siegfried "96-channel microplate surface plasmon resonance fiber optic sensor system", Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II, (21 April 1999); https://doi.org/10.1117/12.346756

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