CT-based assessment of regional pulmonary blood flow parameters: an update

Jehangir K. Tajik; Binh Q. Tran; Eric A. Hoffman

doi:10.1117/12.349588

20 May 1999 CT-based assessment of regional pulmonary blood flow parameters: an update

Jehangir K. Tajik, Binh Q. Tran, Eric A. Hoffman

Proceedings Volume 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images; (1999) https://doi.org/10.1117/12.349588
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

We have previously reported a deconvolution-based technique to recover regional microvascular transport characteristics from dynamic CT images. We have refined our deconvolution algorithm and used Monte Carlo simulations to estimate the error and confidence interval of the resulting regional microvascular mean transit time (MIT) measures. Random errors, assumed to be due to white noise in the imaging process, were superimposed upon known input (PA) and regional parenchymal time-intensity (blood flow) data. The resulting simulated data were then fit to gamma variate functions and processed via our deconvolution algorithm to provide microvascular MTT measures for the simulated curves. The magnitude of the noise used in the simulations was obtained by subtracting two consecutively acquired images (approximately 1.5 sec delay between the two images) from a dynamic imaging sequence of a supine dog imaged at FRC. A total of 35 simulations were performed for each of five sample locations spanning the dependent to nondependent extent of the lungs. Microvascular MTT ranged from 3.39 sec to 9.67 sec as sample locations were moved from dependent to nondependent areas of the lungs. The standard error associated with these measures ranged from plus or minus 0.03 sec in the dependent portion of the lungs to plus or minus 0.27 sec in the non-dependent area of the lungs.

Citation Download Citation

Jehangir K. Tajik, Binh Q. Tran, and Eric A. Hoffman "CT-based assessment of regional pulmonary blood flow parameters: an update", Proc. SPIE 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images, (20 May 1999); https://doi.org/10.1117/12.349588

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available