Multisensory fiber optic probes for PDT dosimetry: construction, performance, and error analysis

Natalie Pomerleau; Lothar D. Lilge

doi:10.1117/12.469334

6 June 2002 Multisensory fiber optic probes for PDT dosimetry: construction, performance, and error analysis

Natalie Pomerleau, Lothar D. Lilge

Proceedings Volume 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI; (2002) https://doi.org/10.1117/12.469334
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) is gradually gaining widespread acceptance as an alternative or adjunct therapy to standard oncologic treatment modalities. Effective PDT treatment is dependent on the interaction of the photosensitizer, treatment light, and molecular oxygen. Much room for improvement exists in the area of PDT dosimetry, especially for deep-seated tumors. To this end, multi-sensory fiber optic probes that detect the fluence rate have been developed. Selected fluorophores are placed in grooves at multiple (1-5) positions along a 250micrometers optical fiber. PLS-based deconvolution of the detected fluorescence emission spectrum yields the fluorescence intensity, and hence the fluence rate, at each sensor location. Single- fluorophore probes were used to elucidate properties of individual sensors. Results with these single-sensor probes, performance with PLS-based algorithm, and preliminary performance of multi-sensor probes will be presented.

Citation Download Citation

Natalie Pomerleau and Lothar D. Lilge "Multisensory fiber optic probes for PDT dosimetry: construction, performance, and error analysis", Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); https://doi.org/10.1117/12.469334

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