Gastroenteric cancers detection by Raman spectroscopy of human serum

Xiaozhou Li; Junxiu Lin

doi:10.1117/12.473598

13 June 2003 Gastroenteric cancers detection by Raman spectroscopy of human serum

Xiaozhou Li, Junxiu Lin

Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.473598
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

To investigate the spectral specialities of stomach cancer serum for diagnosis, fluorescence and Raman spectra of normal, stomach cancer, esophagus cancer and atophic gastritis sera were measured in the visible region in this study. All spectra except esophagus cancer were characterized by three sharp peaks. The intensity of each peak was different in different spectrum. After sampels were radiated by laser, fluorescence weakened along wiht red shift of its band center, and spectral changes of normal and stomach cancer cases were different from other samples. It was also observed that spectral changes of atophic gastritis were very similar with stomach cancer after radiated by laser, however, there are still some distinctions that can be used to differentiate them from each other. A notable difference is that the relative intensity of peak C excited by 488.0nm is higher than excited by 514.5nm in spectrum of stomach cancer, whereas lower in other cases. We utilized it as a criterion and got an accuracy of 80.77% in stomach cancer detection.

Citation Download Citation

Xiaozhou Li and Junxiu Lin "Gastroenteric cancers detection by Raman spectroscopy of human serum", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.473598

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