Saturation of a photochemical dose by photosensitizer bleaching during PDT

Boris Ya. Kogan

doi:10.1117/12.499811

16 October 2003 Saturation of a photochemical dose by photosensitizer bleaching during PDT

Boris Ya. Kogan

Proceedings Volume 5142, Therapeutic Laser Applications and Laser-Tissue Interactions; (2003) https://doi.org/10.1117/12.499811
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Photodynamic therapy (PDT) wit h total photobleaching of a photosensitizer (PS) was studied theoretically. The equations for spatial-temporal distribution of photochemical dose (PD) under various irradiations were obtained. Both surface irradiation and interstitial irradiation were considered. The possibilities of having constant therapeutic dose within a large extent of a tissue and even of obtaining the maximal dose at a particular depth were shown.

Citation Download Citation

Boris Ya. Kogan "Saturation of a photochemical dose by photosensitizer bleaching during PDT", Proc. SPIE 5142, Therapeutic Laser Applications and Laser-Tissue Interactions, (16 October 2003); https://doi.org/10.1117/12.499811

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