Preclinical studies of vascular acting photosensitizer bacteriopheophorbide for the treatment of prostate cancer

Fred W. Hetzel; Qun Chen; David Luck; Jill Beckers; Zheng Huang

doi:10.1117/12.528379

14 June 2004 Preclinical studies of vascular acting photosensitizer bacteriopheophorbide for the treatment of prostate cancer

Fred W. Hetzel, Qun Chen, David Luck, Jill Beckers, Zheng Huang

Author Affiliations +

Proceedings Volume 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII; (2004) https://doi.org/10.1117/12.528379
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) mediated with vascular acting photosensitizer pd-bacteriopheophorbide (Tookad), is investigated as an alternative modality for the total ablation of prostate cancer. In vivo normal canine prostate is used as the animal model. Interstitial PDT was performed by irradiating the surgically exposed prostates with a diode laser (763 nm, 150 mW/cm) to activate the IV infused photosensitizer drug. The prostate and its adjacent tissues were harvested and subjected to histopathological examination. At one-week post PDT, the animals recovered well with little or no urethral complications. Prostatic urethra and prostate adjacent tissues (bladder and underlying colon) were well preserved. PDT induced prostate lesions were characterized by marked hemorrhagic necrosis. Prostate lesions could be detected by MRI scan as early as 48 h post PDT. Maximum lesion size of 1.5 cm³ and 2.9 cm³ could be achieved at 50 J/cm and 100 J/cm, respectively, with interstitial treatment using a single 1-cm diffuser fiber, suggesting the Tookad-PDT is very effective in ablating prostatic tissue. Pharmacokinetic studies show that the photosensitizer is cleared rapidly from the circulation. In conclusion, the novel photosensitizer Tookad mediated PDT may provide an effective alternative to treat localized prostate cancer.

Citation Download Citation

Fred W. Hetzel, Qun Chen, David Luck, Jill Beckers, and Zheng Huang "Preclinical studies of vascular acting photosensitizer bacteriopheophorbide for the treatment of prostate cancer", Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); https://doi.org/10.1117/12.528379

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