Spectroscopic luminescent tomographic imaging for quantitative assessment of hemoglobin oxygenation

Wenxiang Cong; Durairaj Kumar; Alexander Cong; Ge Wang

doi:10.1117/12.595427

20 April 2005 Spectroscopic luminescent tomographic imaging for quantitative assessment of hemoglobin oxygenation

Wenxiang Cong, Durairaj Kumar, Alexander Cong, Ge Wang

Proceedings Volume 5745, Medical Imaging 2005: Physics of Medical Imaging; (2005) https://doi.org/10.1117/12.595427
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

Healthy tissues and tumors exhibit different optical characteristics in blood volume and oxygen sufficiency. Tumor physiology is effectively monitored by non-invasively observing the changes in oxyhemoglobin and deoxyhemoglobin concentration in tissue. In this paper, we present a practical method for quantitative assessment of hemoglobin concentration and blood oxygenation based on the diffusion theory and finite element analysis. The method incorporates prior knowledge on permissible target region, and reduced the reconstruction of chromosphere concentration to an optimization procedure with simple constrain. A numerical simulation study has been conducted by using a heterogeneous phantom. The numerical results show that the reconstruction method has been successfully applied for the reconstruction of the variation of HbO₂ and HbR concentration in numerical simulation experiments.

Citation Download Citation

Wenxiang Cong, Durairaj Kumar, Alexander Cong, and Ge Wang "Spectroscopic luminescent tomographic imaging for quantitative assessment of hemoglobin oxygenation", Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); https://doi.org/10.1117/12.595427

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KEYWORDS

Tissues

Absorption

Diffusion

Blood

Tumors

Numerical simulations

Reconstruction algorithms

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