Computerized nodule detection in thin-slice CT using selective enhancement filter and automated rule-based classifier

Qiang Li; Feng Li; Kunio Doi

doi:10.1117/12.596070

29 April 2005 Computerized nodule detection in thin-slice CT using selective enhancement filter and automated rule-based classifier

Qiang Li, Feng Li, Kunio Doi

Author Affiliations +

Proceedings Volume 5747, Medical Imaging 2005: Image Processing; (2005) https://doi.org/10.1117/12.596070
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

We have been developing computer-aided diagnostic (CAD) scheme to assist radiologists detect lung nodules in thoracic CT images. In order to improve the sensitivity for nodule detection, we developed a selective nodule enhancement filter for nodule which can simultaneously enhance nodules and suppress other normal anatomic structures such as blood vessels and airway walls. Therefore, as preprocessing steps, this filter is useful for improving the sensitivity of nodule detection and for reducing the number of false positives. Another new technique we employed in this study is an automated rule-based classifier. It can significantly reduce the extent of the disadvantages of existing rule-based classifiers, including manual design, poor reproducibility, poor evaluation methods such as re-substitution, and a large overtraining effect. Experimental results performed with Monte Carlo simulation and a real lung nodule CT dataset demonstrated that the automated method can completely eliminate overtraining effect in the procedure of cutoff threshold selection, and thus can minimize overall overtraining effect in the rule-based classifier.

Citation Download Citation

Qiang Li, Feng Li, and Kunio Doi "Computerized nodule detection in thin-slice CT using selective enhancement filter and automated rule-based classifier", Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); https://doi.org/10.1117/12.596070

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