Optical spectroscopy of human blood serum albumin interaction with lead ions

A. Saha; L. Manglass; S. Lionel; A. Sklyarov; E. Sokol; Yu. M. Petrussevich; G. P. Petrova; V. V. Yakovlev

doi:10.1117/12.645294

27 February 2006 Optical spectroscopy of human blood serum albumin interaction with lead ions

A. Saha, L. Manglass, S. Lionel, A. Sklyarov, E. Sokol, Yu. M. Petrussevich, G. P. Petrova, V. V. Yakovlev

Proceedings Volume 6094, Optical Diagnostics and Sensing VI; 60940D (2006) https://doi.org/10.1117/12.645294
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Lead ions in solution interact strongly with human blood serum albumin forming clusters and modifying electronic properties of albumin molecules. We experimentally demonstrate that this interaction can be detected at pM concentrations of lead in solution. The structural and electronic modifications of albumin were observed using Raman, light scattering, fluorescence, and circular dichroism absorption spectroscopies.

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A. Saha, L. Manglass, S. Lionel, A. Sklyarov, E. Sokol, Yu. M. Petrussevich, G. P. Petrova, and V. V. Yakovlev "Optical spectroscopy of human blood serum albumin interaction with lead ions", Proc. SPIE 6094, Optical Diagnostics and Sensing VI, 60940D (27 February 2006); https://doi.org/10.1117/12.645294

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