Quantification of tumor mobility during the breathing cycle using 3D dynamic MRI

Max Schoebinger; Christian Plathow; Ivo Wolf; Hans-Ulrich Kauczor; Hans-Peter Meinzer

doi:10.1117/12.653153

13 March 2006 Quantification of tumor mobility during the breathing cycle using 3D dynamic MRI

Max Schoebinger, Christian Plathow, Ivo Wolf, Hans-Ulrich Kauczor, Hans-Peter Meinzer

Author Affiliations +

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61430P (2006) https://doi.org/10.1117/12.653153
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

Respiration causes movement and shape changes in thoracic tumors, which has a direct influence on the radio-therapy planning process. Current methods for the estimation of tumor mobility are either two-dimensional (fluoroscopy, 2D dynamic MRI) or based on radiation (3D (+t) CT, implanted gold markers). With current advances in dynamic MRI acquisition, 3D+t image sequences of the thorax can be acquired covering the thorax over the whole breathing cycle. In this work, methods are presented for the interactive segmentation of tumors in dynamic images, the calculation of tumor trajectories, dynamic tumor volumetry and dynamic tumor rotation/deformation based on 3D dynamic MRI. For volumetry calculation, a set of 21 related partial volume correcting volumetry algorithms has been evaluated based on tumor surrogates. Conventional volumetry based on voxel counting yielded a root mean square error of 29% compared to a root mean square error of 11% achieved by the algorithm performing best among the different volumetry methods. The new workflow has been applied to a set of 26 patients. Preliminary results indicate, that 3D dynamic MRI reveals important aspects of tumor behavior during the breathing cycle. This might imply the possibility to further improve high-precision radiotherapy techniques.

Citation Download Citation

Max Schoebinger, Christian Plathow, Ivo Wolf, Hans-Ulrich Kauczor, and Hans-Peter Meinzer "Quantification of tumor mobility during the breathing cycle using 3D dynamic MRI", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61430P (13 March 2006); https://doi.org/10.1117/12.653153

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE