AOSLO: from benchtop to clinic

Yuhua Zhang; Siddharth Poonja; Austin Roorda

doi:10.1117/12.681416

29 August 2006 AOSLO: from benchtop to clinic

Yuhua Zhang, Siddharth Poonja, Austin Roorda

Proceedings Volume 6306, Advanced Wavefront Control: Methods, Devices, and Applications IV; 63060V (2006) https://doi.org/10.1117/12.681416
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

We present a clinically deployable adaptive optics scanning laser ophthalmoscope (AOSLO) that features micro-electro-mechanical (MEMS) deformable mirror (DM) based adaptive optics (AO) and low coherent light sources. With the miniaturized optical aperture of a μDMS-Multi^TM MEMS DM (Boston Micromachines Corporation, Watertown, MA), we were able to develop a compact and robust AOSLO optical system that occupies a 50 cm X 50 cm area on a mobile optical table. We introduced low coherent light sources, which are superluminescent laser diodes (SLD) at 680 nm with 9 nm bandwidth and 840 nm with 50 nm bandwidth, in confocal scanning ophthalmoscopy to eliminate interference artifacts in the images. We selected a photo multiplier tube (PMT) for photon signal detection and designed low noise video signal conditioning circuits. We employed an acoustic-optical (AOM) spatial light modulator to modulate the light beam so that we could avoid unnecessary exposure to the retina or project a specific stimulus pattern onto the retina. The MEMS DM based AO system demonstrated robust performance. The use of low coherent light sources effectively mitigated the interference artifacts in the images and yielded high-fidelity retinal images of contiguous cone mosaic. We imaged patients with inherited retinal degenerations including cone-rod dystrophy (CRD) and retinitis pigmentosa (RP). We have produced high-fidelity, real-time, microscopic views of the living human retina for healthy and diseased eyes.

Citation Download Citation

Yuhua Zhang, Siddharth Poonja, and Austin Roorda "AOSLO: from benchtop to clinic", Proc. SPIE 6306, Advanced Wavefront Control: Methods, Devices, and Applications IV, 63060V (29 August 2006); https://doi.org/10.1117/12.681416

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