Autofluorescence spectroscopy for early diagnosis of cancer eye

Shovan K. Majumder; Nirmalya Ghosh; Sopan M. Rathod; Pradeep K. Gupta

doi:10.1117/12.724874

6 February 2007 Autofluorescence spectroscopy for early diagnosis of cancer eye

Shovan K. Majumder, Nirmalya Ghosh, Sopan M. Rathod, Pradeep K. Gupta

Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64301K (2007) https://doi.org/10.1117/12.724874
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We report an in-vitro autofluorescence spectroscopic study of cow eye tissue to explore the applicability of the approach in discriminating early stage "cancer eye" from normal squamous eye tissues. Significant differences were observed in the autofluorescence signatures between the "cancer eye" and normal eye tissues. The spectral differences were quantified by employing a probability-based diagnostic algorithm developed based on recently formulated theory of Relevance Vector Machine (RVM), a Bayesian machine-learning framework of statistical pattern recognition. The algorithm provided sensitivity and specificity values of 97 ± 2% towards cancer for the training set data based on leave-one-out cross validation and a sensitivity of 97 ± 2% and a specificity of 99 ± 1% towards cancer for the independent validation set data. These results suggest that autofluorescence spectroscopy might prove to be a quantitative in-vivo diagnostic modality for early and accurate diagnosis of "cancer eye" in veterinary clinical setting, which would help improve ranch management from both economic and animal care standpoint.

Citation Download Citation

Shovan K. Majumder, Nirmalya Ghosh, Sopan M. Rathod, and Pradeep K. Gupta "Autofluorescence spectroscopy for early diagnosis of cancer eye", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64301K (6 February 2007); https://doi.org/10.1117/12.724874

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissues

Eye

Cancer

Diagnostics

Algorithm development

Luminescence

Spectroscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years