Characterization of laser-induced thermal response of nanoshells for cancer treatment using magnetic-resonance temperature imaging

Andrew M. Elliott; R. Jason Stafford; Jon Schwartz; James Wang; Anil M. Shetty; Chris Bourgoyne; D. Patrick O'Neal; John D. Hazle

doi:10.1117/12.700957

9 February 2007 Characterization of laser-induced thermal response of nanoshells for cancer treatment using magnetic-resonance temperature imaging

Andrew M. Elliott, R. Jason Stafford, Jon Schwartz, James Wang, Anil M. Shetty, Chris Bourgoyne, D. Patrick O'Neal, John D. Hazle

Author Affiliations +

Proceedings Volume 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV; 64400G (2007) https://doi.org/10.1117/12.700957
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Laser induced thermal therapy is used in conjunction with gold coated silica core nanoshells and magneticresonance temperature imaging (MRTI). The nanoshells are embedded in phantom or in vivo tumors and heat preferentially compared to surrounding tissue when the laser is applied. The tissues thermal response is varied by either the laser power or the nanoshell concentration. In this way precise control of the heating can be achieved. This results in the ability to quantitatively monitor therapeutic temperature changes that occur in a spatiotemporally controlled way. This provides an unprecedented means proscribing and monitoring a treatment in real time and the ability to make precise corrections when necessary.

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Andrew M. Elliott, R. Jason Stafford, Jon Schwartz, James Wang, Anil M. Shetty, Chris Bourgoyne, D. Patrick O'Neal, and John D. Hazle "Characterization of laser-induced thermal response of nanoshells for cancer treatment using magnetic-resonance temperature imaging", Proc. SPIE 6440, Thermal Treatment of Tissue: Energy Delivery and Assessment IV, 64400G (9 February 2007); https://doi.org/10.1117/12.700957

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