A catheter-based near-infrared scanning spectroscopy system for imaging lipid-rich plaques in human coronary arteries in vivo

Craig M. Gardner; Jennifer Lisauskas; Edward L. Hull; Huwei Tan; Stephen Sum; Thomas Meese; Chunsheng Jiang; Sean Madden; Jay Caplan; James E. Muller

doi:10.1117/12.737885

2 October 2007 A catheter-based near-infrared scanning spectroscopy system for imaging lipid-rich plaques in human coronary arteries in vivo

Craig M. Gardner, Jennifer Lisauskas, Edward L. Hull, Huwei Tan, Stephen Sum, Thomas Meese, Chunsheng Jiang, Sean Madden, Jay Caplan, James E. Muller

Author Affiliations +

Proceedings Volume 6765, Next-Generation Spectroscopic Technologies; 67650G (2007) https://doi.org/10.1117/12.737885
Event: Optics East, 2007, Boston, MA, United States

Abstract

Although heart disease remains the leading cause of death in the industrialized world, there is still no method, even under cardiac catheterization, to reliably identify those atherosclerotic lesions most likely to lead to heart attack and death. These lesions, which are often non-stenotic, are frequently comprised of a necrotic, lipid-rich core overlaid with a thin fibrous cap infiltrated with inflammatory cells. InfraReDx has developed a scanning, near-infrared, optical-fiber-based, spectroscopic cardiac catheter system capable of acquiring NIR reflectance spectra from coronary arteries through flowing blood under automated pullback and rotation in order to identify lipid-rich plaques (LRP). The scanning laser source and associated detection electronics produce a spectrum in 5 ms at a collection rate of 40 Hz, yielding thousands of spectra in a single pullback. The system console analyzes the spectral data with a chemometric model, producing a hyperspectral image (a Chemogram, see figure below) that identifies LRP encountered in the region interrogated by the system. We describe the system architecture and components, explain the experimental procedure by which the chemometric model was constructed from spectral data and histology-based reference information collected from autopsy hearts, and provide representative data from ongoing ex vivo and clinical studies.

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Craig M. Gardner, Jennifer Lisauskas, Edward L. Hull, Huwei Tan, Stephen Sum, Thomas Meese, Chunsheng Jiang, Sean Madden, Jay Caplan, and James E. Muller "A catheter-based near-infrared scanning spectroscopy system for imaging lipid-rich plaques in human coronary arteries in vivo", Proc. SPIE 6765, Next-Generation Spectroscopic Technologies, 67650G (2 October 2007); https://doi.org/10.1117/12.737885

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