Implementation of nonlinear registration of brain atlas based on piecewise grid system

Rong Liu; Lixu Gu; Jianrong Xu

doi:10.1117/12.749956

14 November 2007 Implementation of nonlinear registration of brain atlas based on piecewise grid system

Rong Liu, Lixu Gu, Jianrong Xu

Proceedings Volume 6789, MIPPR 2007: Medical Imaging, Parallel Processing of Images, and Optimization Techniques; 678905 (2007) https://doi.org/10.1117/12.749956
Event: International Symposium on Multispectral Image Processing and Pattern Recognition, 2007, Wuhan, China

Abstract

In this paper, a multi-step registration method of brain atlas and clinical Magnetic Resonance Imaging (MRI) data based on Thin-Plate Splines (TPS) and Piecewise Grid System (PGS) is presented. The method can help doctors to determine the corresponding anatomical structure between patient image and the brain atlas by piecewise nonlinear registration. Since doctors mostly pay attention to particular Region of Interest (ROI), and a global nonlinear registration is quite time-consuming which is not suitable for real-time clinical application, we propose a novel method to conduct linear registration in global area before nonlinear registration is performed in selected ROI. The homogenous feature points are defined to calculate the transform matrix between patient data and the brain atlas to conclude the mapping function. Finally, we integrate the proposed approach into an application of neurosurgical planning and guidance system which lends great efficiency in both neuro-anatomical education and guiding of neurosurgical operations. The experimental results reveal that the proposed approach can keep an average registration error of 0.25mm in near real-time manner.

Citation Download Citation

Rong Liu, Lixu Gu, and Jianrong Xu "Implementation of nonlinear registration of brain atlas based on piecewise grid system", Proc. SPIE 6789, MIPPR 2007: Medical Imaging, Parallel Processing of Images, and Optimization Techniques, 678905 (14 November 2007); https://doi.org/10.1117/12.749956

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KEYWORDS

Brain

Brain mapping

Image registration

Magnetic resonance imaging

Neuroimaging

Associative arrays

Complex systems

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