Time-domain fluorescence molecular tomography based on experimental data

Limin Zhang; Jiao Li; Feng Gao; Huiyuan He; Huijuan Zhao

doi:10.1117/12.807445

12 February 2009 Time-domain fluorescence molecular tomography based on experimental data

Limin Zhang, Jiao Li, Feng Gao, Huiyuan He, Huijuan Zhao

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71741O (2009) https://doi.org/10.1117/12.807445
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We propose a 3D scheme for time-domain fluorescence molecular tomography within the normalized Born-ratio formulation. A finite element method solution to the Laplace transformed time-domain coupled diffusion equations is employed as the forward model, and the resultant linear inversions at two distinct transform-factors are solved with an algebraic reconstruction technique to separate fluorescent yield and lifetime images. By use of a multichannel time-correlation single photon counting system, we experimentally validate that the proposed scheme can achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

Citation Download Citation

Limin Zhang, Jiao Li, Feng Gao, Huiyuan He, and Huijuan Zhao "Time-domain fluorescence molecular tomography based on experimental data", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741O (12 February 2009); https://doi.org/10.1117/12.807445

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