Background free CARS imaging by local phase detection

M. Jurna; J. P. Korterik; C. Otto; L. Herek; H. L. Offerhaus

doi:10.1117/12.807714

13 February 2009 Background free CARS imaging by local phase detection

M. Jurna, J. P. Korterik, C. Otto, L. Herek, H. L. Offerhaus

Proceedings Volume 7183, Multiphoton Microscopy in the Biomedical Sciences IX; 718310 (2009) https://doi.org/10.1117/12.807714
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In this article we show that heterodyne CARS, based on a controlled and stable phase-preserving chain, can be used to measure amplitude and phase information of molecular vibration modes. The technique is validated by a comparison of the imaginary part of the heterodyne CARS spectrum to the spontaneous Raman spectrum of polyethylene. The detection of the phase allows for rejection of the non-resonant background from the data. The resulting improvement of the signal to noise ratio is shown by measurements on a sample containing lipid.

Citation Download Citation

M. Jurna, J. P. Korterik, C. Otto, L. Herek, and H. L. Offerhaus "Background free CARS imaging by local phase detection", Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 718310 (13 February 2009); https://doi.org/10.1117/12.807714

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