Photodynamic therapy influence on anti-cancer immunity

O. G. Isaeva; V. A. Osipov

doi:10.1117/12.853588

11 February 2010 Photodynamic therapy influence on anti-cancer immunity

O. G. Isaeva, V. A. Osipov

Proceedings Volume 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics; 754704 (2010) https://doi.org/10.1117/12.853588
Event: Saratov Fall Meeting 2009, 2009, Saratov, Russian Federation

Abstract

The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of IL-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce the tumor. These findings indicate the important role of anti-cancer immune response in the long-term tumor control after PDT.

Citation Download Citation

O. G. Isaeva and V. A. Osipov "Photodynamic therapy influence on anti-cancer immunity", Proc. SPIE 7547, Saratov Fall Meeting 2009: International School for Junior Scientists and Students on Optics, Laser Physics, and Biophotonics, 754704 (11 February 2010); https://doi.org/10.1117/12.853588

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