Quality controls and delineation protocol of PET/CT gated acquisition in function of the movement amplitude, size of spheres and signal over background ratio

Cyril Jaudet; David Didierlaurent; Julia Nalis; Lawrence O. Dierickx; Olivier Caselles; Frederic Courbon

doi:10.1117/12.877829

16 March 2011 Quality controls and delineation protocol of PET/CT gated acquisition in function of the movement amplitude, size of spheres and signal over background ratio

Cyril Jaudet, David Didierlaurent, Julia Nalis, Lawrence O. Dierickx, Olivier Caselles, Frederic Courbon

Author Affiliations +

Proceedings Volume 7961, Medical Imaging 2011: Physics of Medical Imaging; 796143 (2011) https://doi.org/10.1117/12.877829
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

This study presents quality controls and segmentation tools for gated acquisition imaging of moving tumors. We study the effect of different amplitudes in a bin in function of sizes of spheres and signal to background ratios. Simple rules are then derived to establish which bins are appropriate to quantify tumor activity and to delineate volume. Finally the threshold technics for gated acquisition exams are discussed in function of the different parameters. Our experimental setup consisted of a movable platform, a thorax phantom with 6 fillable spheres and a real time position management device allowing to synchronize the PET/CT image with movement. The spheres were filled with F-Fluoro-2-deoxy-glucose and the activity in the tank was adjusted to obtain signal to background ratios from 3.5 to 20 (228 combinations of experimental parameters were studied). Maximal activity, optimal threshold and elongation of the sphere images between static and moving tumors were then compared with our own matlab program. Significant changes had appearing for movement superior to 7.5 mm in a bin leading to an activity decrease, an increase of the optimal threshold and an elongation in the movement direction. These effects were accentuated for low SBR and a sphere diameter inferior to 20 mm. The optimal threshold value was around 35% for large spheres and high SBR. This value increase when the sphere size and the SBR decrease. We then deduce from our measurements the relevant parameters for the delineation procedure. In conclusion, the effect of movement were successfully quantified in function of the sphere size, SBR and movement in a bin. Calibration threshold curves are now available in a clinical routine used for gated acquisitions.

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Cyril Jaudet, David Didierlaurent, Julia Nalis, Lawrence O. Dierickx, Olivier Caselles, and Frederic Courbon "Quality controls and delineation protocol of PET/CT gated acquisition in function of the movement amplitude, size of spheres and signal over background ratio", Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 796143 (16 March 2011); https://doi.org/10.1117/12.877829

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