Biodistribution and clearance of quantum dots in small animals

Yana F. Salykina; Victoria V. Zherdeva; Sergey V. Dezhurov; Maxim S. Wakstein; Marina V. Shirmanova; Elena V. Zagaynova; Andrey A. Martyanov; Alexander P. Savitsky

doi:10.1117/12.888959

12 April 2011 Biodistribution and clearance of quantum dots in small animals

Yana F. Salykina, Victoria V. Zherdeva, Sergey V. Dezhurov, Maxim S. Wakstein, Marina V. Shirmanova, Elena V. Zagaynova, Andrey A. Martyanov, Alexander P. Savitsky

Author Affiliations +

Proceedings Volume 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII; 799908 (2011) https://doi.org/10.1117/12.888959
Event: Saratov Fall Meeting 2010, 2010, Saratov, Russian Federation

Abstract

CdSe-core, ZnS-capped semiconductor nanoparticles - quantum dots (QDs) - have been at the forefront of biomedical nanotechnology research thanks to their unique optical Η photophysical properties. In the present study the impact of the particle coating and size on their in vivo fate after intravenous (IV) injection into mice was studied by fluorescence methods. For this study, we compared organ-selective biodistribution and elimination routes of synthesized QDs coated with 3-mercaptopropionic acid (QD MPA) and commercially available Qtracker 705 nontargeted quantum dots with poly(ethylene glycol) coating (QD PEG). We observed primary accumulation of these QDs in lung. Experiments demonstrated that QD MPA and QD PEG have both remained fluorescent in lung after at least 24 hours postinjection. Moreover, QDs was seen to deposit mainly in liver, spleen, kidney and lymph nodes. We also concluded that QDs MPA and QDs 705 are both sequestered and not excreted with feces or urine.

Citation Download Citation

Yana F. Salykina, Victoria V. Zherdeva, Sergey V. Dezhurov, Maxim S. Wakstein, Marina V. Shirmanova, Elena V. Zagaynova, Andrey A. Martyanov, and Alexander P. Savitsky "Biodistribution and clearance of quantum dots in small animals", Proc. SPIE 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII, 799908 (12 April 2011); https://doi.org/10.1117/12.888959

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available