Applying laser speckle images to skin science: skin lesion differentiation by polarization

Tim K. Lee; Lioudmila Tchvialeva; Gurbir Dhadwal; Bahman Sotoodian; Sunil Kalai; Haishan Zeng; Harvey Lui; David I. McLean

doi:10.1117/12.919976

22 November 2011 Applying laser speckle images to skin science: skin lesion differentiation by polarization

Tim K. Lee, Lioudmila Tchvialeva, Gurbir Dhadwal, Bahman Sotoodian, Sunil Kalai, Haishan Zeng, Harvey Lui, David I. McLean

Author Affiliations +

Proceedings Volume 8338, Tenth International Conference on Correlation Optics; 83381E (2011) https://doi.org/10.1117/12.919976
Event: Correlation Optics 2011, 2011, Chernivsti, Ukraine

Abstract

Skin cancer is a worldwide health problem. It is the most common cancer in the countries with a large white population; furthermore, the incidence of malignant melanoma, the most dangerous form of skin cancer, has been increasing steadily over the last three decades. There is an urgent need to develop in-vivo, noninvasive diagnostic tools for the disease. This paper attempts to response to the challenge by introducing a simple and fast method based on polarization and laser speckle. The degree of maintaining polarization estimates the fraction of linearly maintaining polarization in the backscattered speckle field. Clinical experiments of 214 skin lesions including malignant melanomas, squamous cell carcinomas, basal cell carcinomas, nevi, and seborrheic keratoses demonstrated that such a parameter can potentially diagnose different skin lesion types. ROC analyses showed that malignant melanoma and seborrheic keratosis could be differentiated by both the blue and red lasers with the area under the curve (AUC) = 0.8 and 0.7, respectively. Also malignant melanoma and squamous cell carcinoma could be separated by the blue laser (AUC = 0.9), while nevus and seborrheic keratosis could be identified using the red laser (AUC = 0.7). These experiments demonstrated that polarization could be a potential in-vivo diagnostic indicator for skin diseases.

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Tim K. Lee, Lioudmila Tchvialeva, Gurbir Dhadwal, Bahman Sotoodian, Sunil Kalai, Haishan Zeng, Harvey Lui, and David I. McLean "Applying laser speckle images to skin science: skin lesion differentiation by polarization", Proc. SPIE 8338, Tenth International Conference on Correlation Optics, 83381E (22 November 2011); https://doi.org/10.1117/12.919976

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