Analysis of conventional swept-source OCT of subglottic stenosis in a
rabbit model

Ashley Hamamoto; Erica Su; Ya-Sin Peaks; Zhongping Chen; Brian J. F. Wong

doi:10.1117/12.2014252

8 March 2013 Analysis of conventional swept-source OCT of subglottic stenosis in a rabbit model

Ashley Hamamoto, Erica Su, Ya-Sin Peaks, Zhongping Chen, Brian J. F. Wong

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 856521 (2013) https://doi.org/10.1117/12.2014252
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Acquired subglottic stenosis is a narrowing of the airway caused by prolonged endotracheal intubation. Currently, there are no non-invasive means to diagnose the disease. A previous study by this same group introduced optical coherence tomography (OCT) as a means of monitoring the progression of stenosis. The aim of the current study was to qualitatively and quantitatively analyze OCT images obtained from a subglottic stenosis model of the rabbit airway. 15 rabbits were used throughout the study, and a MEMs based OCT probe was utilized. The OCT images obtained were analyzed using a free software program, 3D Slicer. The region of scarred tissue was grown out and measured quantitatively. This study demonstrated the feasibility of using a program to quantify the progression of scarring in OCT images, in addition to qualitatively correlating between histology, endoscopic, and OCT images. Future works may include utilization of a long-range probe and use of a pressure necrosis model to better emulate the actual onset of neonatal subglottic stenosis.

Citation Download Citation

Ashley Hamamoto, Erica Su, Ya-Sin Peaks, Zhongping Chen, and Brian J. F. Wong "Analysis of conventional swept-source OCT of subglottic stenosis in a rabbit model", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856521 (8 March 2013); https://doi.org/10.1117/12.2014252

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available