Rat coronary microangiography system for preclinical imaging using synchrotron radiation

Keiji Umetani; James T. Pearson; Daryl O. Schwenke; Mikiyasu Shirai

doi:10.1117/12.2006570

19 March 2013 Rat coronary microangiography system for preclinical imaging using synchrotron radiation

Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai

Author Affiliations +

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 866864 (2013) https://doi.org/10.1117/12.2006570
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

A rat microangiography system using a synchrotron radiation source was developed at SPring-8 to enable in vivo visualization of coronary arteries for vascular-based functional imaging. Angiographic images of beating hearts were obtained with spatial resolution in the micrometer range and temporal resolution in the millisecond range using a new rotating-disk X-ray shutter and an X-ray direct-conversion type detector. Quantitative evaluations of the imaging system were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. Small blood vessels of around 50 μm diameter were visualized clearly at heart rates of 350–400 per minute. Apparent vasodilation compared to baseline vessel diameters was observed by infusion of vasoactive agents. The microangiography system enables direct investigation of the mechanisms of vascular dysfunction.

Citation Download Citation

Keiji Umetani, James T. Pearson, Daryl O. Schwenke, and Mikiyasu Shirai "Rat coronary microangiography system for preclinical imaging using synchrotron radiation", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 866864 (19 March 2013); https://doi.org/10.1117/12.2006570

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