IRF-calibrated Born normalization scheme for time-domain diffuse fluorescence tomography based on overlap time-gating

Feng Gao; Pengxi Liu; Wenbo Wan; Jiao Li; Huijuan Zhao

doi:10.1117/12.2035615

17 February 2014 IRF-calibrated Born normalization scheme for time-domain diffuse fluorescence tomography based on overlap time-gating

Feng Gao, Pengxi Liu, Wenbo Wan, Jiao Li, Huijuan Zhao

Author Affiliations +

Proceedings Volume 8937, Multimodal Biomedical Imaging IX; 89370O (2014) https://doi.org/10.1117/12.2035615
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The full time-resolved methods of diffuse fluorescence tomography (DFT) are known to improve image resolution and accuracy significantly. However, these methods usually suffer from low practical efficacy due to the influence of the instrumental response function (IRF) and the tradeoff between the used data time-resolution and the required signal-to-noise ratio (SNR). We herein present a full time-resolved approach that combines an IRF-calibrated time-resolved Born normalization and an overlap-delaying time-gating strategy for attaining high SNR without sacrificing the time-resolved information content. Phantom experiments demonstrate that the approach outperforms the traditional DFT methods in spatial resolution and reconstruction fidelity.

Citation Download Citation

Feng Gao, Pengxi Liu, Wenbo Wan, Jiao Li, and Huijuan Zhao "IRF-calibrated Born normalization scheme for time-domain diffuse fluorescence tomography based on overlap time-gating", Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370O (17 February 2014); https://doi.org/10.1117/12.2035615

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