10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor

Keiichiro Kagawa; Taishi Takasawa; Zhang Bo; Min-Woong Seo; Kaita Imai; Jotaro Yamamoto; Masataka Kinjo; Susumu Terakawa; Keita Yasutomi; Shoji Kawahito

doi:10.1117/12.2041131

4 March 2014 10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor

Keiichiro Kagawa, Taishi Takasawa, Zhang Bo, Min-Woong Seo, Kaita Imai, Jotaro Yamamoto, Masataka Kinjo, Susumu Terakawa, Keita Yasutomi, Shoji Kawahito

Author Affiliations +

Proceedings Volume 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII; 894713 (2014) https://doi.org/10.1117/12.2041131
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

To observe molecular transport in a living cell, a high-speed CMOS image sensor for multi-point fluorescence correlation spectroscopy is developed. To achieve low-noise and high-speed simultaneously, a prototype CMOS image sensor is designed based on a complete pixel-parallel architecture and multi-channel pipelined pixel readout. The prototype chip with 10×10 effective pixels is fabricated in 0.18-μm CMOS image sensor technology. The pixel pitch and the photosensitive area are 56μm and 10μm in diameter without a microlens, respectively. In the experiment, the total sampling rate of 606kS/s is achieved. The measured average random noise is 24.9LSB, which is equivalent to about 2.5 electrons in average.

Citation Download Citation

Keiichiro Kagawa, Taishi Takasawa, Zhang Bo, Min-Woong Seo, Kaita Imai, Jotaro Yamamoto, Masataka Kinjo, Susumu Terakawa, Keita Yasutomi, and Shoji Kawahito "10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor", Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 894713 (4 March 2014); https://doi.org/10.1117/12.2041131

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available