Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development

Lars R. Furenlid; Harrison H. Barrett; H. Bradford Barber; Eric W. Clarkson; Matthew A. Kupinski; Zhonglin Liu; Gail D. Stevenson; James M. Woolfenden

doi:10.1117/12.2064808

20 October 2014 Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development

Lars R. Furenlid, Harrison H. Barrett, H. Bradford Barber, Eric W. Clarkson, Matthew A. Kupinski, Zhonglin Liu, Gail D. Stevenson, James M. Woolfenden

Author Affiliations +

Proceedings Volume 9186, Fifty Years of Optical Sciences at The University of Arizona; 91860J (2014) https://doi.org/10.1117/12.2064808
Event: SPIE Optical Engineering + Applications, 2014, San Diego, California, United States

Abstract

During the past two decades, researchers at the University of Arizona’s Center for Gamma-Ray Imaging (CGRI) have explored a variety of approaches to gamma-ray detection, including scintillation cameras, solid-state detectors, and hybrids such as the intensified Quantum Imaging Device (iQID) configuration where a scintillator is followed by optical gain and a fast CCD or CMOS camera. We have combined these detectors with a variety of collimation schemes, including single and multiple pinholes, parallel-hole collimators, synthetic apertures, and anamorphic crossed slits, to build a large number of preclinical molecular-imaging systems that perform Single-Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), and X-Ray Computed Tomography (CT). In this paper, we discuss the themes and methods we have developed over the years to record and fully use the information content carried by every detected gamma-ray photon.

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Lars R. Furenlid, Harrison H. Barrett, H. Bradford Barber, Eric W. Clarkson, Matthew A. Kupinski, Zhonglin Liu, Gail D. Stevenson, and James M. Woolfenden "Molecular imaging in the College of Optical Sciences: an overview of two decades of instrumentation development", Proc. SPIE 9186, Fifty Years of Optical Sciences at The University of Arizona, 91860J (20 October 2014); https://doi.org/10.1117/12.2064808

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