Quantitative phase imaging of cellular and subcellular structures for non-invasive screening diagnostics of socially significant diseases

Irina Vasilenko; Vladislav Metelin; Marat Nasyrov; Vladimir Belyakov; Alexander B. Kuznetsov; Evgeniy Sukhenko

doi:10.1117/12.2078661

11 March 2015 Quantitative phase imaging of cellular and subcellular structures for non-invasive screening diagnostics of socially significant diseases

Irina Vasilenko, Vladislav Metelin, Marat Nasyrov, Vladimir Belyakov, Alexander B. Kuznetsov, Evgeniy Sukhenko

Author Affiliations +

Proceedings Volume 9336, Quantitative Phase Imaging; 93362K (2015) https://doi.org/10.1117/12.2078661
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The objective of the present study is to increase the quality of the early diagnosis using cytological differential-diagnostic criteria for reactive changes in the nuclear structures of the immunocompetent cells. The morphofunctional status of living cells were estimated in the real time using new technologic platform of the hardware-software complex for phase cell imaging. The level of functional activity for lymphocyte subpopulations was determined on the base of modification of nuclear structures and decreasing of nuclear phase thickness. The dynamics of nuclear parameters was used as the quantitative measuring for cell activating level and increasing of proliferative potential.

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Irina Vasilenko, Vladislav Metelin, Marat Nasyrov, Vladimir Belyakov, Alexander B. Kuznetsov, and Evgeniy Sukhenko "Quantitative phase imaging of cellular and subcellular structures for non-invasive screening diagnostics of socially significant diseases", Proc. SPIE 9336, Quantitative Phase Imaging, 93362K (11 March 2015); https://doi.org/10.1117/12.2078661

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