Robust detection of multiple sclerosis lesions from intensity-normalized multi-channel MRI

Yogesh Karpate; Olivier Commowick; Christian Barillot

doi:10.1117/12.2082032

20 March 2015 Robust detection of multiple sclerosis lesions from intensity-normalized multi-channel MRI

Yogesh Karpate, Olivier Commowick, Christian Barillot

Proceedings Volume 9413, Medical Imaging 2015: Image Processing; 941314 (2015) https://doi.org/10.1117/12.2082032
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Multiple sclerosis (MS) is a disease with heterogeneous evolution among the patients. Quantitative analysis of longitudinal Magnetic Resonance Images (MRI) provides a spatial analysis of the brain tissues which may lead to the discovery of biomarkers of disease evolution. Better understanding of the disease will lead to a better discovery of pathogenic mechanisms, allowing for patient-adapted therapeutic strategies. To characterize MS lesions, we propose a novel paradigm to detect white matter lesions based on a statistical framework. It aims at studying the benefits of using multi-channel MRI to detect statistically significant differences between each individual MS patient and a database of control subjects. This framework consists in two components. First, intensity standardization is conducted to minimize the inter-subject intensity difference arising from variability of the acquisition process and different scanners. The intensity normalization maps parameters obtained using a robust Gaussian Mixture Model (GMM) estimation not affected by the presence of MS lesions. The second part studies the comparison of multi-channel MRI of MS patients with respect to an atlas built from the control subjects, thereby allowing us to look for differences in normal appearing white matter, in and around the lesions of each patient. Experimental results demonstrate that our technique accurately detects significant differences in lesions consequently improving the results of MS lesion detection.

Citation Download Citation

Yogesh Karpate, Olivier Commowick, and Christian Barillot "Robust detection of multiple sclerosis lesions from intensity-normalized multi-channel MRI", Proc. SPIE 9413, Medical Imaging 2015: Image Processing, 941314 (20 March 2015); https://doi.org/10.1117/12.2082032

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