Fei Tian,1 Jouha Min,2,3 Jiri Kanka,4 Paula T. Hammond,2,3 Henry Du1
1Stevens Institute of Technology (United States) 2Massachusetts Institute of Technology (United States) 3David H. Koch Institute for Integrative Cancer Research (United States) 4Institute of Photonics and Electronics of the ASCR, v.v.i. (Czech Republic)
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA]n polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA]n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy.
Fei Tian,Jouha Min,Jiri Kanka,Paula T. Hammond, andHenry Du
"In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions", Proc. SPIE 9480, Fiber Optic Sensors and Applications XII, 948005 (3 June 2015); https://doi.org/10.1117/12.2191683
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Fei Tian, Jouha Min, Jiri Kanka, Paula T. Hammond, Henry Du, "In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions," Proc. SPIE 9480, Fiber Optic Sensors and Applications XII, 948005 (3 June 2015); https://doi.org/10.1117/12.2191683