Fiber optic label-free biophotonic diagnostic tool for cardiovascular disease

Cristina Rius; Tobias N. Ackermann; Beatriz Dorado; Xavier Muñoz-Berbel; Vicente Andrés; Andreu Llobera

doi:10.1117/12.2179062

12 June 2015 Fiber optic label-free biophotonic diagnostic tool for cardiovascular disease

Cristina Rius, Tobias N. Ackermann, Beatriz Dorado, Xavier Muñoz-Berbel, Vicente Andrés, Andreu Llobera

Proceedings Volume 9518, Bio-MEMS and Medical Microdevices II; 95180V (2015) https://doi.org/10.1117/12.2179062
Event: SPIE Microtechnologies, 2015, Barcelona, Spain

Abstract

A label-free compact method for performing photonic characterization of "healthy" versus "diseased" arteries has been developed. It permits the detection of atherosclerotic lesion in living mouse arteries. Using this prototype, we observed that the spectral response (photonic fingerprint, PIN) obtained from aortas of wild-type mice differs from the response of ApoE-KO mice fed with high-fat diet (an atheroprone mouse model). Benchmark of the results against gold standard was performed by staining the aortas with Oil-Red-O to visualize atherosclerotic plaques.

Citation Download Citation

Cristina Rius, Tobias N. Ackermann, Beatriz Dorado, Xavier Muñoz-Berbel, Vicente Andrés, and Andreu Llobera "Fiber optic label-free biophotonic diagnostic tool for cardiovascular disease", Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180V (12 June 2015); https://doi.org/10.1117/12.2179062

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